2015 Fiscal Year Final Research Report
Elucidating pathogenesis and developing novel biomarkers for idiopathic pulmonary fibrosis based on the ethnic difference
| Project/Area Number |
25860646
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 間質性肺炎 / 特発性肺線維症 / 急性呼吸不全 / 急性増悪 / バイオマーカー / 人種差 |
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| Outline of Final Research Achievements |
Idiopathic pulmonary fibrosis, one of the Intractable Diseases in Japan, shows an acute deterioration and a resultant death in a short period, which has been named as acute exacerbation. We analyzed the Japanese and German patients with idiopathic pulmonary fibrosis, and demonstrated a significant ethnic difference in the incidence of acute exacerbation between the cohorts. The single nucleotide polymorphisms in TERT and Ang2 genes were associated with the incidence of acute exacerbation. In addition, GDF-15 protein was a novel biomarker for the diagnosis and predicting survival in idiopathic pulmonary fibrosis.
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| Free Research Field |
間質性肺炎急性増悪に伴う急性呼吸不全の病態解明および新規治療法開発
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