2015 Fiscal Year Final Research Report
Elucidation of the role of 27-hydroxycholesterol in chronic obstructive pulmonary disease
| Project/Area Number |
25860652
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 閉塞性肺疾患 |
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| Outline of Final Research Achievements |
We showed that 27-hydroxycholesterol (27-OHC) augmented the release of MMP-2 and MMP-9 in lung fibroblasts. 27-OHC-augmented MMPs release was promoted by nitrosative-stress-mediated NF-κB activation and subsequent TGF-β1 release. Diseased human lung fibroblasts from patients with COPD were significantly more susceptible for the 27-OHC-induced release of MMPs than normal adult human lung fibroblasts. This is the first report that showed 27-OHC augmented MMPs release and nitrosative stress. 27-OHC has the potential to be the original biomarker and therapeutical target of COPD.
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| Free Research Field |
呼吸器内科学
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