The utility of detection of fibers and particles in BALF by electron microscopy in pulmonary fibrosis.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860664
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: KIDO Takashi 産業医科大学, 医学部, 講師 (30389465)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 電子顕微鏡 / 石綿 / 粉塵 / 肺線維症 / びまん性肺疾患 / 成分解析 / 光学顕微鏡 / 気管支肺胞洗浄液

Outline of Final Research Achievements

We have evaluated the utility of electron microscopy in the analysis of asbesots, fibers and particles in bronchoalveolar lavage fluid (BALF) of 107 patients with diffuse lung diseases incluiding pulmonary fibrosis. In the detection of asbestos, electron microscopy using BALF seemed to be superior to light microscopy using BALF and displayed a similar sensitivity to light microscopy using surgically-obtained lung tissue samples. Our results also suggest that detection of elements in particles is useful for evaluating occupational exposure.

Free Research Field

呼吸器内科