2014 Fiscal Year Final Research Report
The regulatory mechanisms of the CD80 expression in the podocytes.
| Project/Area Number |
25860666
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IMAIZUMI Tadaatsu 弘前大学, 大学院医学研究科, 教授 (90232602)
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| Research Collaborator |
NARITA Ikuyo
FUKUSHI Yasuyo
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 糸球体上皮細胞 / CD80 |
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| Outline of Final Research Achievements |
In minimal change disease (MCD), T cell-disorder hypothesis has been proposed, but has not been proved. CD80 is one of the co-stimulatory molecules which helps T cell activation. Recently, the increased expression of CD80 in the podocytes and in the urine was demonstrated in MCD. We hypothesized that the disorder of the regulatory mechanism of CD80 could be the cause of MCD. Therefore, we used cultured podocytes and investigated the expressions of the interleukin-10 and cytotoxic T-lymphocyte-associated protein 4 which usually regulate CD80.
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| Free Research Field |
腎臓内科学
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