2014 Fiscal Year Final Research Report
Novel therapeutic strategy for diabetic nephropathy targeting PGC-1 alpha-ERR alpha pathway
| Project/Area Number |
25860680
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 糖尿病性腎症 / 核内受容体 / ポドサイト |
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| Outline of Final Research Achievements |
This study examined the therapeutic effects for diabetic nephropathy targeting estrogen-related receptor-alpha (ERRa), which involves mitochondrial function and angiogenesis. In glomeruli from type 1 diabetic mouse model, expression of ERRa was increased on podocytes. Cultured podocytes treated with ERRa antagonist showed to decrease expression of VEGF in high-glucose condition. Diabetic ERRa knockout mice could not reduce proteinuiria compared to wild type diabetic mice. However, kaempferol, which is known as ERRa inverse agonist, suppressed proteinuria in diabetic mouse model. These results suggest the potential involvement of ERRa in the progression of diabetic nephropathy.
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| Free Research Field |
腎臓内科学
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