The role of mitochondrial function and mitophagy in the pathogenesis of acute kidney injury

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860683
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Kochi University
• Principal Investigator: Oode Kazu 高知大学, 医学部附属病院, 医員 (40589537)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 急性腎障害 / 尿細管障害 / オートファジー / マイトファジー

Outline of Final Research Achievements

We have reported that both autophagy and apoptosis were related to the pathogenesis in acute kidney injury (AKI). However, the roles of autophagy and mitophagy in the pathogenesis of renal disease are poorly understood. Because proximal tubules highly include mitochondria, the tubules that could prevent apoptosis by autophagy and mitophagy might be possibly related to dedifferentiation and regeneration. We reported that sestrin, p53-related gene, which induced by ischemia-repurfusion in proximal tubules, suppressed apoptosis and further progressed autophagy in AKI model using GFP-LC3-TG mice that could recognize autophagy in vivo.

Free Research Field

腎臓病学