Epigenetic regulation of podocyte phenotype through KLF4

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860687
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Keio University
• Principal Investigator: Hayashi Kaori 慶應義塾大学, 医学部, 助教 (60445294)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 慢性腎臓病 / 蛋白尿 / ポドサイト / エピゲノム

Outline of Final Research Achievements

We have shown that transcription factor Kruppel-like factor 4 (KLF4) modulates podocyte epigenome and attenuates proteinuria（Hayashi, et al. J Clin Invest. 2014). Moreover, we demonstrated that renin-angiotensin system (RAS) blockade reset podocyte epigenome through KLF4 in part（Hayashi, et al. Kidney Int. 2015). These results provide a new concept that RAS blockade can exert therapeutic effects through epigenetic modulation of the kidney gene expression, and suggest a novel therapeutic approach for treatment of proteinuric kidney diseases.

Free Research Field

腎臓、高血圧