Plasma PTX3 levels as a useful biomarker for assessing mortality risk in Japanese hemodialysis patients with nutritional risk

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860695
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: MIYAMOTO Tetsu 産業医科大学, 医学部, 非常勤医師 (30611305)
• Co-Investigator(Kenkyū-buntansha): OTSUJI Yutaka 産業医科大学, 教授 (30264427) ; TAMURA Masahito 産業医科大学病院腎センター, 診療教授 (40330980)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ペントラキシン３ / 栄養リスク / 血液透析 / バイオマーカー

Outline of Final Research Achievements

In this multicenter prospective cohort study comprising 380 maintenance hemodialysis patients, we investigated the effect of plasma PTX3 levels on all-cause mortality, with a particular focus on nutritional risk. In patients in the high nutritional risk group (GNRI<91.2), a significant correlation was evident between high PTX3 levels (> 6.29 ng/mL)and mortality risk. Plasma PTX3 levels may be a useful biomarker for assessing mortality risk in Japanese hemodialysis patients, especially those with high nutritional risk. Concurrent measurement of other inflammatory markers such as CRP and IL-6 is expected to improve the predictive power of PTX3. Furthermore, the association between CRP and nutritional risk calculated on the basis of GNRI depends on albumin levels, yet PTX3 had a strong association with anthropometric parameters.

Free Research Field

腎臓内科