2015 Fiscal Year Final Research Report
Analysis of mitochondrial regulation by DJ-1
| Project/Area Number |
25860697
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Hokkaido University |
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Principal Investigator |
NIKI Kazuko 北海道大学, 薬学研究科(研究院), 助教 (50447645)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | DJ-1 / PARK7 |
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| Outline of Final Research Achievements |
Secreted DJ-1 from astrocytes protected co-cultured neurons against oxidative stress, while the DJ-1 mutants discovered in PARK7 did not. DJ-1 directly interacts with Beclin and this binding was promoted by oxidation of DJ-1. There are different views on the function of DJ-1 in autophagy. Then, I investigated whether DJ-1 promote or suppress autophagy, and then it became clear that DJ-1 promotes autophagy. We identified KIF1B as target substrate for DJ-1 protease. It is possible that DJ-1 regulate mitochondrial transport through cleavage of KIF1B.
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| Free Research Field |
分子生物学
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