2014 Fiscal Year Final Research Report
The pathogenesis of GEM bodies reduction in ALS affected tissues.
| Project/Area Number |
25860703
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ALS / U snRNAs / GEM小体 / スプライシング |
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| Outline of Final Research Achievements |
Our object is the elucidation of ALS pathogenesis. We have already found the reduction of minor spliceosomal U snRNA and GEM bodies in ALS affected tissues. U snRNA is main component of the splicing machinery and GEM bodies have important role in the maturation of U snRNAs. We intended to clarify the pathogenesis of GEM bodies reduction and aberrant splicing in ALS affected tissues. In this study, we found the reduction of SMN mRNA in TDP-43 depleted cells. SMN protein is main component of GME bodies. And there were minor spliceosome dependent splicing aberrations in ALS affected tissues.
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| Free Research Field |
医歯薬学
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