2016 Fiscal Year Final Research Report
A study of the pathomechanism in early-onset dementia due to macrophage colony stimulating factor receptor gene mutations.
| Project/Area Number |
25860704
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Kunihiro 信州大学, 医学部, 特任教授 (90242693)
|
|---|
| Research Collaborator |
KINOSHITA Michiaki 諏訪赤十字病院, 神経内科, 医師
KONDO Yasufumi 信州大学, 医学部, 助教
MATSUSHIMA Akira 鹿教湯三才山リハビリテーションセンター鹿教湯病院, 神経内科, 医師
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | HDLS / コロニー刺激因子1受容体 |
|---|
| Outline of Final Research Achievements |
Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is characterized by early-onset cognitive dysfunction caused by mutations in the colony-stimulating factor 1 receptor (CSF1R ) gene.We performed biochemical examinations on autopsied brains from patients with HDLS. Our results suggests decreased protein expression of CSF1R in HDLS brain. In analysis of peripheral blood mononuclear cells from HDLS patients suggests impaired induction and survival of macrophages under stimulation with CSF-1 and IL-34.
|
| Free Research Field |
神経内科学
|
