2014 Fiscal Year Final Research Report
The effects of dieatry yeasts on experimental autoimmune encephalomyelitis
Project/Area Number |
25860712
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Keywords | 多発性硬化症 / 腸管免疫 / 酵母 |
Outline of Final Research Achievements |
The intestinal microflora affects the pathogenesis of several autoimmune diseases by influencing immune system function. We aimed to investigate the effects of various dietary yeasts contained in fermented foods on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). The effects of eight yeasts selected from 18 types of yeasts contained in fermented foods were examined. Of these, administration of Candida kefyr ameliorated the severity of EAE. Reduced numbers of inflammatory cells, and increased regulatory T cells and dendritic cells were observed. Analysis of microflora of C. kefyr-treated mice demonstrated decreased Bacteroides compared to control flora. Transfer of intestinal microbiota also resulted in decreased Bacteroides and ameliorated symptoms of EAE. Thus, oral administration of C. kefyr ameliorated EAE by altering the microflora. In addition, our findings also suggested the potential health benefits of dietary yeasts.
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Free Research Field |
神経内科
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