Search for the causative gene in consanguineous families with Parkinson's disease

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860725
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Juntendo University
• Principal Investigator: Li Yuanzhe 順天堂大学, 医学(系)研究科(研究院), 助教 (40549292)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 家族性パーキンソン病

Outline of Final Research Achievements

This study identified 25 candidate variants for Parkinson’s disease by Genome-wide linkage analysis and whole-exome sequencing in four consanguineous families with Parkinson’s disease (FPD). We did not find any of the twenty-five candidate variants in 100 normal Japanese controls. Then, I performed mutation analysis of the 25 candidate variants on 500 patients with FPD. However, we did not detect any mutations. I still cannot conclude whether those 25 variants are the causative mutations for FPD. Therefore, we need further investigations to identify the genes responsible for FPD.

Free Research Field

分子遺伝学