Cardiac complication of myositis associated with anti-mitochondrial antibodies

2016 Fiscal Year Final Research Report

• Project/Area Number: 25860731
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Okinaka Memorial Institute for Medical Research
• Principal Investigator: MAEDA MEIKO 公益財団法人冲中記念成人病研究所, その他部局等, 研究員 (20646799)
• Research Collaborator: Shimizu Jun 東京大学, 附属病院神経内科, 准教授 ; Uesaka Yoshikazu 国家公務員共済組合連合会, 虎の門病院神経内科, 部長
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 筋炎 / 自己抗体 / 心臓合併症 / 呼吸筋合併症

Outline of Final Research Achievements

Eighteen AMA-positive myositis patients with cardiac complications (11 females and 7 males) were identified. The ages at onset of symptom ranged from 36 to 70 years (mean, 50.1 ± 9.0 years). Duration between the onsets of symptom to end of follow-up (disease courses) ranged 1.5 to 18.0 years (mean, 9.0 ± 5.2 years). All patients were associated with arrhythmia and had decreased EF ranging 9 to 71 % (mean, 40.2 ± 17.2 %). Ten patients required intervention therapy (catheter ablation, n=7; defibrillator, n=3; pacemaker, n=2; mitral valve surgery, n=1). Four patients died in the follow-up period including two patients who died suddenly. Histopathological analysis revealed that the biopsied specimen of all the patients fulfilled the criteria of non-specific myositis.

Free Research Field

神経筋病理