2014 Fiscal Year Final Research Report
The roles of the autonomic nervous system in the control of energy metabolism
| Project/Area Number |
25860735
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 肥満 / 自律神経 / エネルギー代謝 / 肝糖代謝 / 褐色脂肪組織 / 心臓 |
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| Outline of Final Research Achievements |
We have found that hepatic activation of glucose metabolism by glucokinase overexpression induced reduction in resting heart rate. Hepatic glucokinase-induced afferent vagal signal suppressed the neuronal activity of the rostral raphe pallidus (rRPa), which controls cardiac sympathetic nerve activity. Thus, this liver-to-heart interaction is mediated by a neuronal pathway consisting of hepatic vagal afferent, rRPa and cardiac sympathetic efferent. This neuronal relay may act as a protective mechanism against leptin-induced tachycardia and hypertension.
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| Free Research Field |
医歯薬学
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