Role of metabolic inter-organ network mediated by hepatic amino acid signaling

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860736
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Tohoku University
• Principal Investigator: UNO Kenji 東北大学, 大学病院, 助教 (50596632)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: アミノ酸代謝 / メタボリックシンドローム / 肥満 / mTOR

Outline of Final Research Achievements

Metabolic processes in different organs are regulated in a coordinated manner via both neuronal signals and humoral factors. We have previously demonstrated that neuronal networks, originating in the liver, play important roles in maintaining glucose and energy homeostasis, by enhancing pancreatic beta cell mass and energy consumption, respectively. Nutrient overloads due to food energy excess affect these metabolic regulations, resulting in progression of obesity and metabolic disorders. In this study, we aim to discover a new mechanism of hepatic amino acid signaling on the development of metabolic syndrome from the point of view of inter-organ network. At this stage, we have identified that hepatic amino acid signaling is involved in the regulation of systemic lipid metabolism.

Free Research Field

医歯薬学