2014 Fiscal Year Final Research Report
The novel mechanism of improving insulin resistance by sphingosine 1-phosphate
| Project/Area Number |
25860740
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KURANO Makoto 東京大学, 医学部附属病院, 助教 (60621745)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | アポ蛋白M / スフィンゴシン1-リン酸 / インスリン抵抗性 |
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| Outline of Final Research Achievements |
In this study, we investigated the involvement of sphingosine 1-phosphate (S1P), a potent bioactive lipid mediator, and apolipoprotein M (apoM), a carrier and modulator of S1P, in the pathogenesis of diabetes. We found with animal experimetns that apoM and S1P exert anti-diabetic properties by improving insulin resistance in liver and promoting insulin secretion from beta-cell. We also observed that both plasma and hepatic contents of apoM and S1P are increased in streptozotocin-induced diabetic mice and mice fed with high fat diet. These results suggest the possibility of applying apoM and S1P into clinical laboratory medicine and therapeutic medicine in the fields of diabetes.
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| Free Research Field |
代謝学
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