Role of fractalkine-CX3CR1for regulation of insulin resistance

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860745
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Kanazawa University
• Principal Investigator: NAGASHIMADA Mayumi 金沢大学, 脳・肝インターフェースメディシン研究センター, 博士研究員 (30645510)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ケモカイン / 慢性炎症 / インスリン抵抗性 / フラクタルカイン / CX3CR1 / 肥満

Outline of Final Research Achievements

The physiological and pathophysiological role of fractalkine and its receptor CX3CR1 in diseases are complex and not fully understood. In particular, it is not known how fractalkine-CX3CR1 can regulate obesity-associated chronic inflammation and metabolic diseases. Here, we investigated the role of fractalkine and CX3R1 system in obesity-induced inflammation and insulin resistance. We found that CX3CR1 deficient mice showed that insulin resistance, glucose intolerance, and hepatic steatosis in response to high fat (HF) feeding. These data suggested that fractalkine-CX3CR1 signal play a crucial role in development of insulin resistance. Further studies to clarify the mechanism by which fractalkine-CX3CR1 regulate inflammation and insulin resistance are going on.

Free Research Field

代謝学