2014 Fiscal Year Final Research Report
Identification of noncoding RNAs cooperating with Evi1
| Project/Area Number |
25860783
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ARAI Shunya 東京大学, 医学部附属病院, 講師 (00579716)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 白血病 |
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| Outline of Final Research Achievements |
Evi1 is one of epigenetic regulators, which is thought to work in cooperation with long noncoding RNA (lncRNA). I showed that Evi1 and a lncRNA, HOTAIR, have physical interaction in a leukemia cell line with high levels of Evi1 expression. I also revealed that a lncRNA, CRNDE, was overexpressed in immortalized hematopoietic cells with high levels of Evi1 expression. Those cells were phenotypically unchanged after knockdown of the expression of CRNDE.
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| Free Research Field |
血液内科学
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