2014 Fiscal Year Final Research Report
The role of Sirt1 in arthritis
| Project/Area Number |
25860807
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 免疫学 / 遺伝子 |
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| Outline of Final Research Achievements |
Rheumatoid arthritis ( RA )is inflammatory disease which may lead to joint destructionwithout treatment.Osteoclasts play a important role in joint destruction in RA.So,inhibition of differentiation of osteoclast may lead to the treatment of RA.We investicated the role of Sirt1 in differentiation of Osteoclast.It is indicated that Sirt1 may negatively regulate the differentiation of Osteoclasts which play a important role in obstruction of joints in arthritis.
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| Free Research Field |
リウマチ・膠原病
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