2015 Fiscal Year Final Research Report
A novel treatment strategy aiming joint regeneration of rheumatoid arthritis and osteoarthritis by mesenchymal stem cells with nano-fiber scaffold
| Project/Area Number |
25860821
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 関節再生 / 関節リウマチ / スキャフォールド |
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| Outline of Final Research Achievements |
Mesenchymal stem cells (MSCs) have immunosuppressive activity and can differentiate into bone and cartilage; and thus seem ideal for treatment of rheumatoid arthritis (RA) and osteoarthritis (OA). Here, we investigated the immunosuppressive potential, osteogenesis and chondrogenesis potentials of MSCs seeded onto nano-fiber scaffolds (NFs). Healthy donor derived human MSC seeded on NF sheet (NF-MSC) successfully suppressed the collagen induced arthritis of rats. In this context, NFs enhanced the ability of MSCs of cytokines production. Next, in vitro experiment of NF-MSC revealed that NFs stimulated the differentiation of MSCs derived from healthy as well as RA- or OA-patients into osteoblasts, chondrocytes and osteocytes. These data show the possible use of NF-MSCs for the repair of RA-affected joints.
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| Free Research Field |
骨代謝
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