Mechanisms of non atopic airway inflammation

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860822
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: National Research Institute for Child Health and Development
• Principal Investigator: MORITA Hideaki 独立行政法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 研究員 (90365320)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 気道炎症 / IL-33 / マスト細胞 / 制御性T細胞 / 自然免疫リンパ球 / プロテアーゼ

Outline of Final Research Achievements

We found that the plant-derived cysteine protease, which is homologous to house dust mite protease, induce production of IL-33 by lung epithelial cells, resulting in development of allergic eosinophilic airway inflammation. We also found that IL-33 can play an anti-inflammatory/immunosuppressive negative-feedback role by inducing regulatory T cells through mast cells while promoting allergic inflammation through innate lymphoid cells

Free Research Field

内科学