2016 Fiscal Year Final Research Report
Investigation of the neural mechanisms underlying autism based on the hypothesis of functional imbalance between frontal and parietal region
| Project/Area Number |
25860841
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Tohoku University (2016)
Hamamatsu University School of Medicine (2013-2015) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKI YASUYUKI 東北大学, 加齢医学研究所機能画像医学研究分野, 教授 (10375115)
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| Research Collaborator |
TSUCHIYA KENJI 浜松医科大学, 子どもの心の発達研究センター, 教授 (20362189)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 自閉巣ペクトラム症 |
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| Outline of Final Research Achievements |
Autism spectrum disorder (ASD) is characterized by restricted interests and impaired social communication. One of the most specific cognitive characteristics of ASD is imbalanced cognitive profile shown in psychological test or in real life. However, there have been no test or neuro-imaging approaches to evaluate the quantity of this imbalance. Our purpose was to develop such approaches. We examined the performances of ASD individuals of the tasks related to adaptation to novel and typical daily situations (these tasks were developed by our previous study), and detected ASD-specific imbalanced pattern. We also found that the imbalance of cortical activities linked to these tasks were correlated with the severity of ASD. furthermore, we detected another autistic imbalanced findings in brain; imbalanced proportion of the density of neural fiber between the cortical regions related to language production and those related to comprehension of others' mind.
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| Free Research Field |
小児神経学
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