2014 Fiscal Year Final Research Report
Roll of HMGB1 and innate immune system in vasculitis of Kawasaki disease
| Project/Area Number |
25860843
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 川崎病 / 血管炎 / 冠動脈 / 自然免疫 |
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| Outline of Final Research Achievements |
We investigated the roll of HMGB1 in vasculitis of Kawasaki disease using CAWS-induced mouse model. Treatment by anti-HMGB1 antibodies significantly reduced the inflammation score of vasculitis, and also reduced the level of IL-6 in CAWS-treated mice. We also revesled that HMGB1 is highly expressed in the lesion of vasculits of mice using immunohistochemistry. We elucidated that HMGB1 plays a critical roll in the vasculitis of the murine model of Kawasaki disease.
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| Free Research Field |
小児循環器学
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