An effective anti tumor immunity induced by autologous hematopoietic stem cell transplanta.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860849
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: University of Fukui
• Principal Investigator: SUZUKI Koji 福井大学, 医学部附属病院, 助教 (10397268)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 腫瘍免疫 / 造血幹細胞移植 / 骨髄由来抑制性細胞 / がん微小環境

Outline of Final Research Achievements

Autologous stem cell transplantation（ASCT) was usualy known as a rescue at myelosupression folowed by high dose chemotherapy for reflactory solid tumor. Although autoimmunity cannot have any effect for tumor antigen, we developed the new strategy inducing the effective autoimmunity by the ASCT. Gemcitabine which was known the effect of reducing of myeloid derived suppressor cells, lead immune responce to the tumor antigen. So, we used gemcitabine for pre immunizing agent in donor immunity and transplantaition of these immune cells could get a more powrful anti tumor effect by ASCT. Now, we conferm these result and mechanism. In the feture, these result will be useful for develop new ASCT rejimen in clinical settting.

Free Research Field

小児がん、血液疾患