Food allergy sensitized through epicutaneous

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860851
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: University of Fukui
• Principal Investigator: kawakita akiko 福井大学, 医学部附属病院, 特命助教 (00584856)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 食物アレルギー / 経皮感作 / 免疫療法 / 動物モデル

Outline of Final Research Achievements

Recently, epicutaneous sensitization has got attention as a novel sensitization pathway for food allergy. We established a murine model of food allergy caused by epicutaneous sensitization, in which antigen and vitamin D3 analog (MC903) as an adjuvant were epicutaneously administered and then the antigen was orally challenged to induce immediate type of allergic diarrhea. Repetitive oral challenges increased serum levels of mucosal mast cell protease-1, which correlated with the severity of induced symptoms. Th2 cytokine mRNA expression was increased in the skin. Th2 reactions in skin and activation of mucosal mast cells may play important roles in the development of food allergy. Their regulation might alleviate induced food allergy symptoms.

Free Research Field

小児、免疫・アレルギー