2015 Fiscal Year Final Research Report
Elucidation of the role of redox-active protein in severe influenza (pneumonia, encephalopathy)
| Project/Area Number |
25860865
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
YAMADA Mutsuko 岡山大学, 大学院医歯薬学総合研究科・小児科, 非常勤研究員
FUJII Yousuke 岡山大学, 大学院医歯薬学総合研究科・小児科, 助教 (80549775)
NOSAKA Nobuyuki 岡山大学病院, 小児科, 医員 (30713961)
TSUKAHARA Hirokazu 岡山大学, 大学院医歯薬学総合研究科小児医科学, 教授 (90207340)
MORISHIMA Tsuneo 岡山大学, 大学院医歯薬学総合研究科小児医科学, 特命教授 (90157892)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 小児感染症学 / インフルエンザ / 酸化ストレス |
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| Outline of Final Research Achievements |
TBP2KO mouse was suggested possibility of a metabolic disorder type influenza encephalopathy (Reye syndrome) model mice. In addition redox-active protein of TRX and anti-HMGB1 antibody has been shown to be effective in severe influenza pneumonia in mice. It is expected to confirm the therapeutic effect using a drug with anti-oxidative and anti-inflammatory effect in encephalopathy model mice.
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| Free Research Field |
感染免疫
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