2014 Fiscal Year Final Research Report
The analysis between HHV-6B and medial temporal lobe epilepsy
| Project/Area Number |
25860888
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Fujita Health University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | ヒトヘルペスウイルス6 / 内側側頭葉硬化症 / 宿主遺伝子発現 |
|---|
| Outline of Final Research Achievements |
We analyzed brain samples of intractable epilepsy patients who took neurosurgery in order to elucidate association between mesial temporal lobe sclerosis (MTS) which is intractable epilepsy and human herpesvirus 6 (HHV-6). HHV-6 was the most detected virus in 8 human herpesviruses. And HHV-6 DNA loads were significantly higher in the MTS than non-MTS patients.
Some host gene expressions were significantly higher levels in MTS patients with HHV-6 than those without HHV-6. These results suggested that the association between MTS and HHV-6.
|
| Free Research Field |
小児科
|
