2015 Fiscal Year Final Research Report
Developing a novel therapy with anti-A receptor antibody for perinatal brain injuries
| Project/Area Number |
25860907
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
Saito Akiko 名古屋大学, 医学部附属病院, 病院助教 (50615276)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 周産期低酸素性虚血性脳症 |
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| Outline of Final Research Achievements |
It is urgent to develop novel therapies for infants with perinatal hypoxic-ischemic encephalopathy (HIE). In the present project, we evaluated whether anti-A receptor antibody can exert treatment effect against perinatal HIE or not with perinatal HIE mice. We found that intraperitoneal injection of anti-A receptor antibody suppressed apoptosis, leading to smaller infarct volume. Anti-A receptor antibody injected intraperitoneally could migrated into injured brain, and increased serum cytokine A level significantly.
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| Free Research Field |
新生児学
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