The correration between Serum neutrophil gelatinase-associated lipocalin and bronchopulmonary dysplasia

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860913
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kyushu University
• Principal Investigator: ICHIYAMA MASAKO 九州大学, 医学(系)研究科(研究院), 研究員 (00645989)
• Research Collaborator: OCHIAI Masayuki 九州大学病院, 総合周産期センター, 臨床講師 (90507782)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 気管支肺異形成 / NGAL / 早産児

Outline of Final Research Achievements

Although the pathogenesis of bronchopulmonary dysplasia (BPD) remains unclear, the development of BPD has been reported to be associated with pulmonary inflammation. To search for the correlation between BPD and serum neutrophil gelatinase-associated lipocalin (NGAL), serum levels of NGAL at birth were measured and assessed in the association of BPD. The median NGAL levels and neutrophil counts at birth in BPD group (n=16) were higher than non-BPD group (n=20) (p=0.012). Higher NGAL levels at birth showed a significant association with BPD (p<0.01). The serum levels of NGAL at birth might be an early predictive marker for BPD in preterm infants. We then evaluated the relationship among the hematological features, clinical course and radiological severity (chest CT scoring) of BPD infants (n=73). SGA and sustained inflammation until 28 day of life were associated with aggravation of BPD.

Free Research Field

新生児