2016 Fiscal Year Final Research Report
Neonatal autophagy assessment as a new indicator of initial nutrition plan
| Project/Area Number |
25860914
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | オートファジー / 新生児 / 臍帯 |
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| Outline of Final Research Achievements |
Autophagy is thought to be a mechanism of starvation response immediately after birth. The aim of this study was to establish the method of evaluation for autophagy indicator (LC3-Ⅱ) from frozen specimens of newborn umbilical cord immediately after birth and to correlate them with clinical background.
With Western blotting method, It became possible to semiquantitate LC3-Ⅱ expression level from human frozen umbilical cord. The expression level of LC3-Ⅱ tended to positive correlate with neonatal blood glucose and total protein on admission. Further studies are needed on whether autophagy is involved in nutritional production or embryonic development in neonates.
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| Free Research Field |
新生児学
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