2014 Fiscal Year Final Research Report
Novel therapeutic strategies for atopic dermatitis
Project/Area Number |
25860926
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Dermatology
|
Research Institution | Hokkaido University |
Principal Investigator |
HAMASAKA ASUKA 北海道大学, 医学(系)研究科(研究院), 客員研究員 (60598382)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Keywords | アトピー性皮膚炎 |
Outline of Final Research Achievements |
In this study, I aimed to establish a new therapeutic strategy for atopic dermatitis by increasing filaggrin expression in the epidermis of the patients. I confirmed that some of the AD patients are heterozygous for nonsense or frameshift mutations in the gene encoding filaggrin. These results suggest a possibility that compounds that up-regulate the filaggrin gene promoter can be a potent therapeutic option for atopic dermatitis. This novel therapeutic approach may also be effective for prevention of atopic dermatitis.
|
Free Research Field |
皮膚科学
|