2014 Fiscal Year Final Research Report
Possible roles of adiponetin in a mouse model of psoriasis
Project/Area Number |
25860935
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Dermatology
|
Research Institution | The University of Tokyo |
Principal Investigator |
SHIBATA Sayaka 東京大学, 医学部附属病院, 助教 (50613105)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Keywords | 乾癬 / アディポネクチン |
Outline of Final Research Achievements |
Accumulating epidemiologic evidence has revealed that metabolic syndrome is an independent risk factor for psoriasis development and is associated with more severe psoriasis. Adiponectin, primarily recognized as a metabolic mediator of insulin sensitivity, has been newly drawing attention as a mediator of immune responses. Here we demonstrate that adiponectin regulates skin inflammation, especially IL-17-related psoriasiform dermatitis. Mice with adiponectin deficiency show severe psoriasiform skin inflammation with enhanced infiltration of IL-17-producing dermal gd T cells. Adiponectin directly acts on murine dermal gd T cells to suppress IL-17 synthesis via AdipoR1. We furthermore demonstrate here that exogenous adiponectin rescues exacerbated dermatitis in adiponetin knock-out mice. Our data provide a regulatory role of adiponectin in skin inflammation, which would imply a mechanism underlying the relationship between psoriasis and metabolic disorders.
|
Free Research Field |
皮膚科学
|