2014 Fiscal Year Final Research Report
Analysis of antitumor effect against human melanoma by using STAT3 inhibitor (human-rR9-GRIM19)
| Project/Area Number |
25860941
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 腫瘍免疫 / STAT3 / GRIM-19 |
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| Outline of Final Research Achievements |
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is common in many human and murine cancer cells, and its activation leads to cellular transformation. STAT3 pathway inhibitors have been reported to suppress cancer growth. Previously, We generated an R9-PTD-containing GRIM-19 fusion protein (rR9-GRIM19) and successfully induced overexpression in the cytoplasm of cancer cells. In murine model, rR9-GRIM19 suppressed cell growth in vitro and in vivo. In this research we generated human-rR9-GRIM19 protein and analyze the antitumor effect of this protein against human melanoma cell line.
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| Free Research Field |
皮膚免疫
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