2015 Fiscal Year Final Research Report
The mechanism of immunosuppressive treatment in systemic sclerosis.
| Project/Area Number |
25860955
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 全身性強皮症 / サイトカイン |
|---|
| Outline of Final Research Achievements |
At first, we examined the levels of proteins which extracted from skin sample of patients with systemic sclerosis (SSc) by the ELISA Array analysis. We focused on CD70 and IL-16 that were highly expressed before treatment and down-regulated after immunosuppressive therapy.Next, we performed immunohistochemistry of involved skin specimen. CD70-CD27 and IL-16 were overexpressed in the skin of SSc patients. Furthermore, soluble CD27 and IL-16 were also highly expressed in the sera of SSc patients by the sandwich ELISA.
In conclusion, CD70-CD27 signaling and IL-16 are upregulated in SSc patients, and the activated T lymphocytes might play an important role in the pathogenesis of SSc.
|
| Free Research Field |
皮膚
|
