Clarification of hair regeneration mechanism by hair cycle control molecule Tsukushi

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860957
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Kumamoto University
• Principal Investigator: Niimori Daisuke 熊本大学, 医学部附属病院, 特任助教 (70635789)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: Tsukushi / 毛髪再生 / 創傷治癒

Outline of Final Research Achievements

Previously, we reported that Tsukushi (TSK), a member of the small leucine-rich repeat proteoglycan family, functions as a key extracellular coordinator of multiple signalling networks. In this study, we investigated the contribution of TSK to hair regeneration. Analysis of wound tissue in heterozygous TSK-lacZ knock-in mice revealed neoepidermis, macrophages, myofibroblasts and new born hair follicles. Quantitative PCR and in vitro cell induction experiments revealed that TSK controls macrophage function and myofibroblast differentiation by inhibiting TGF-β1 secreted from macrophages.

Free Research Field

皮膚科学