2016 Fiscal Year Final Research Report
Defective maintenance of pH of stratum corneum can induce atopic dermatitis
| Project/Area Number |
25860958
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
HATANO YUTAKA
FUJIWARA SAKUHEI
HIROSE HARUNA
ZHANG WEI
Jeong Se Kyoo
Elias Peter M.
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | アトピー性皮膚炎 / 角層pH |
|---|
| Outline of Final Research Achievements |
We investigated the homeostasis of stratum coreneum (SC) pH on the pathogenesis of atopic dermatitis (AD). In consequence, it was confirmed that defective maintenance of pH of SC is correlated with preferential emergence and exacerbation of AD-like dermatitis in flaky tail mice. Furthermore, we showed combined benefits of a PAR2 inhibitor and SC acidification for murine AD, suggesting the importance of homeostasis of SC pH and maintenance of acidic SC pH on the pathogenesis of AD.
|
| Free Research Field |
アトピー性皮膚炎
|
