2014 Fiscal Year Final Research Report
The mechanism of the antiperspirant action of aluminum chloride for treatment of hyperhidrosis
| Project/Area Number |
25860970
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 多汗症 / 汗腺 / 汗管 / 塩化アルミニウム / 角化 |
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| Outline of Final Research Achievements |
There has been no report on the mechanism of the antiperspirant action of topical aluminum chloride (AC) for treatment of palmoplantar hyperhidrosis. In this study, we investigated the mechanism of the antiperspirant action of AC.
Histological examination revealed that the eccrine sweat duct in the stratum corneum after AC treatment was filled with keratinous materials. It is suggesting that the antiperspirant action of AC for treatment of palmar hyperhidrosis was caused by blockade of the keratinous materials. The levels of marker molecules relating keratinization were increased by AC treatment in vitro. These results were indicated that AC treatment stimulates the keratinization and consequently blockade of the keratinous materials. In summary, our results provide new insights into the mechanism of the antiperspirant action of AC for treatment of hyperhidrosis.
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| Free Research Field |
発汗障害の原因解明と新規治療法の開発
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