The analyses of altered neural oscillations in schizophrenia

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860990
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: KIRIHARA Kenji 東京大学, 医学部附属病院, 助教 (80553700)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 神経オシレーション / ミスマッチ陰性電位 / 脳波 / 統合失調症 / 臨床病期

Outline of Final Research Achievements

The objective of this study is to investigate neural activity in early stages of schizophrenia. We recorded electroencephalography in patients with first-episode schizophrenia, individuals at ultra-high risk, and healthy control subjects. We found reduction of mismatch negativity amplitude and alterations of neural oscillations in early stages of schizophrenia. These findings suggest that mismatch negativity and neural oscillations may be useful biomarkers for early stages of schizophrenia.

Free Research Field

精神医学