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2014 Fiscal Year Final Research Report

Pre-stress performance in an operant learning predicts post-stress behavioral alterations in chronically stressed rats

Research Project

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Project/Area Number 25860994
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionKanazawa University

Principal Investigator

IGUCHI Yoshio  金沢大学, 医学系, 博士研究員 (20452097)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywordsうつ病 / 慢性ストレス / ストレス反応性 / 個体差 / 意欲 / 柔軟な意思決定 / 欲求性オペラント学習 / 側坐核
Outline of Final Research Achievements

Although chronic stress has been widely used to induce depression-like phenotypes in preclinical studies, a few models have been developed to study causal relationship between the individual differences in the depression-like phenotypes and the pre-existing individual differences prior to stress exposure, which might genetically/epigenetically determine the fate of each animal after stress. We focused on a large inter-individual variability of a group of outbred rats in performance of an appetitive operant (leverpress) trained on a progressive ratio (PR) schedule. Based on the PR performance, we classified animals into 4 subgroups, which were found to show distinctive cognitive/behavioral characteristics. Moreover, the 4 subgroups revealed different behavioral responses to a chronic unpredictable stress (CUS) on short- and long-term bases. These results suggest that the individual differences in the pre-CUS PR performance can predict the distinctive post-CUS behavioral phenotypes.

Free Research Field

精神薬理学

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Published: 2016-06-03  

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