2014 Fiscal Year Annual Research Report
広汎性発達障害の二次障害に対するアリピプラゾールの効果：実行機能の観点からの検討
| Project/Area Number |
25860996
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
石飛 信 独立行政法人国立精神・神経医療研究センター, 精神保健研究所 児童・思春期精神保健研究部, 室長 (50464053)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 自閉症スペクトラム障害 / aripiprazole / 併存症 |
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| Outline of Annual Research Achievements |
自閉症スペクトラム障害（ASD)では、衝動行為・自傷・パニックなどの併存症がしばしばみられ、患者本人およびその家族のQOL を大きく阻害する。非定型抗精神病薬の一つであるAripiprazole は、国外での臨床試験において上記の併存症への有効性が示されているが、本邦における有効性、安全性の検証は行われていない。また、その併存症の改善にいたるメカニズムについて詳細に検討した研究は皆無である。。本研究では、
様々な臨床評価尺度を用いた包括的かつ多角的な症状評価により、aripiprazole の有効性と安全性について検討することを目的とした。29名のASD児・者(male 25, female 4. age range, 6-20 years; mean ± SD age, 11.2 ± 3.4 years) において、12週間にわたりaripiprazoleの効果をAberrant Behavior Checklist (ABC)を用いて詳細に評価した。
結果：Twenty eight subjects received a mean initial and final aripiprazole
dosage of 2.36 ± 0.95 mg/day , 2.87 ± 1.36 mg/day, respectively. The mean scores of the ABC-I at baseline and end point were 18.10 and 10.07, respectively (p <0.01). No significant changes in vital signs, electrocardiogram, or laboratory measures occurred. Body mass index (BMI) increased from a mean value of 18.12 at baseline to 19.23 at end point (p < 0.01).⇒The results suggest that low dose aripiprazole may be effectiveand well tolerated for irritability in subjects with ASD. However, significant increase of BMI was observed, which suggests the potential metabolic adverse effects even when using low dose aripiprazole. Additional long-term controlled studies are needed to evaluate the efficacy and the safety of low dose aripiprazole in subjects with ASD.
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Research Products
(10 results)
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[Journal Article] Attenuation of the contingency detection effect in the extrastriate body area in Autism Spectrum Disorder.2014
Author(s)
Yuko Okamoto., Ryo Kitada., Hiroki C. Tanabe., Masamichi J. Hayashi., Takanori Kochiyama., Toshio Munesue.,Makoto Ishitobi., Daisuke N. Saito., Hisakazu T. Yanaka., Masao Omori., Yuji Wada., Hidehiko Okazawa., Akihiro T. Sasaki., Tomoyo Morita., Shoji Itakura., Hirotaka Kosaka., Norihiro Sadato.
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Journal Title
Neuroscience Research.
Volume: 87
Pages: 66–76
Peer Reviewed
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[Journal Article] Distinguishing between autism spectrum disorder and attention deficit hyperactivity disorder by using behavioral checklists, cognitive assessments, and neuropsychological test battery.2014
Author(s)
Naomi Matsuura., Makoto Ishitobi., Sumiyoshi Arai., Kaori Kawamura., Mizuki Asano., Keisuke Inohara., Tadamasa Narimoto.,Yuji Wada., Michio Hiratani., Hirotaka Kosaka
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Journal Title
Asian Journal of Psychiatry.
Volume: 12
Pages: 50-57
Peer Reviewed
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