2015 Fiscal Year Final Research Report
Omics Analysis of Schizophrenia
Project/Area Number |
25860999
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Nagoya University |
Principal Investigator |
YOSHIMI Akira 名古屋大学, 医学(系)研究科(研究院), 研究員 (00637671)
|
Research Collaborator |
OZAKI Norio 名古屋大学, 医学系研究科, 教授 (40281480)
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Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 統合失調症 / 網羅的解析 / プロテオーム / トランスクリプトーム / 分子精神医学 / ゲノム医学 / バイオインフォマティクス |
Outline of Final Research Achievements |
Omics (genome, transcriptome, and proteome) analysis of lymphoblastoid cell line (LCL) derived from schizophrenia patients and healthy controls was conducted to explore the key molecules underlying the pathophysiology of schizophrenia. The subtle differences between schizophrenics and controls in gene and protein levels were detected, and they were related to the molecular mechanisms that contribute to the pathophysiology of schizophrenia. In addition, we successfully constructed logistic regression models with good discriminative ability between schizophrenics and controls and detected a number of regulatory SNPs by integrating data from genotype and expression wise analysis (expression quantitative trait loci: eQTL).
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Free Research Field |
臨床精神薬理学
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