Endophenotypes and functional analysis of schizophrenia risk gene TCF4

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861002
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: FUJIMOTO Michiko 大阪大学, 医学部附属病院, 医員 (50647625)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 統合失調症 / 中間表現型 / 遺伝子多型 / 遺伝子解析 / 生物学的精神医学

Outline of Final Research Achievements

Transcription factor 4 (TCF4) gene polymorphism is reported to be associated with the human brain function in the genome-wide association study (GWAS). The previous paper showed that the TCF4 polymorphism rs2958182 was related with schizophrenia in Han Chinese. Since rs2958182 is also a common polymorphism in Japanese, we performed the association study between TCF4 and schizophrenia in Japanese population. In our study, the patients with the risk allele T of rs2958182 showed low Novelty Seeking in the Temperament and Character Inventory, a self-administered questionnaire. We also found the gray matter volume of the posterior cingulum was smaller in the patients with the risk allele T of rs2958182 than that in the patients without risk allele T.

Free Research Field

医歯薬学