2014 Fiscal Year Final Research Report
Effect of alcohol on GABAA receptors and Cl- transporters
| Project/Area Number |
25861035
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
MIZUNO Koji 川崎医科大学, 医学部, 講師 (10551046)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | alcohol / GABA / Cl- / NKCC1 |
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| Outline of Final Research Achievements |
GABAA receptor alpha6 subunit and NKCC1 were up-regulated in alcohol dependent model mice. In addition, bumetanide suppressed chronic intermittent alcohol-induced alcohol consumption. In vitro study showed that alcohol induced GABAA receptor alpha6 subunit up-regulation via cRel activation. These findings indicated that the reagent for modulation of intracellular Cl- concentration may be useful to treat the alcohol dependence.
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| Free Research Field |
精神神経薬理学
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