Gamma band auditory response with neuroimaging in mood disorder

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861044
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: National Hospital Organization, Hizen Psychiatric Center
• Principal Investigator: HIRONORI Kuga 独立行政法人国立病院機構肥前精神医療センター(臨床研究部), その他部局等, 研究員 (50639903)
• Research Collaborator: UENO Takefumi 肥前精神医療センター, 臨床研究部長 (00441668) ; ORIBE Naoya 肥前精神医療センター, 脳生理, 神経画像研究室員 (70730498) ; KANBA Shigenobu 九州大学, 医学研究院, 教授 (50195187) ; ONITSUKA Toshiaki 九州大学, 医学研究院, 准教授 (00398059) ; HIRANO Yoji 九州大学, 医学研究院, 助教 (90567497) ; NAKAMURA Itta 九州大学, 医学研究院 ; OKAMOTO Hiroshi 九州大学, 医学研究院 (80724690)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 気分障害 / 双極性感情障害 / うつ病性障害 / 聴性定常反応 / 機能的MRI / 脳波

Outline of Final Research Achievements

The aim of this study was to investigate the difference between bipolar disorder and major depressive disorder. The functioning of the neural circuitry was assessed using the auditory steady state response (ASSR). Left hemispheric neuronal deficits in response to speech sounds in patients with schizophrenia compared to healthy subjects and bipolar disorder.
Reduced 40 Hz auditory steady-state responses in patients with bipolar disorder compared to healthy subjects and major depressive disorder. We also found that cingulate gyrus might be involved in the abnormality of BOLD response to ASSR. It may be useful for discrimination of psychiatric diseases to use these auditory responses.

Free Research Field

精神医学