2015 Fiscal Year Final Research Report
Analysis of the mechanism of the radiation resistance in non-small cell lung cancer
| Project/Area Number |
25861069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
Okano Naoko 群馬大学, 医学部附属病院, 助教 (00647349)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 放射線抵抗性 / がん幹細胞 |
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| Outline of Final Research Achievements |
This studies were aimed to clarify if the carbon ion beam was superior to X-ray resistant cells of non-small cell lung cancer and the molecular biological mechanisms of radio resistance. At first, we calculated the Relative Biological Effectiveness (RBE) of carbon ion beam to X-ray and irradiated the cells by the dose computed with RBE. Then we attempted to derive radiation-resistant cells used with flow cytometry system and antibody to cell surface antigens, but we couldn’t identify expressed factors in radio resistant cells and couldn’t derive selectively.
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| Free Research Field |
放射線腫瘍学
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