Study of comprehensive method to evaluate radiation therapy using three-dimensional analysis of biological effective dose (BED)

2016 Fiscal Year Final Research Report

• Project/Area Number: 25861070
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Fukushima Medical University (2015-2016); Saitama Medical University (2014); Gunma University (2013)
• Principal Investigator: Tamaki Tomoaki 福島県立医科大学, 医学部, 准教授 (20400749)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 放射線治療 / 生物効果線量 / 体外照射 / 腔内照射 / 小線源治療 / 線量分布解析 / 子宮頸癌

Outline of Final Research Achievements

In radiotherapy for cervical cancer, external beam radiaton therapy and intracavitary brachytherapy are applied in combination, but there were no established methods to evaluate the therapeutic effectiveness comprehensively. In this research, a comprehensive method to evaluate not only the 3-dimensional distributions of physical dose but also biological effectiveness dose (BED) was established. This analysis showed that the 3-dimensional evaluation of BED in the combination of central-shielding pelvis irradiation and intracavitary brachytherapy implemented in Japan was feasible and that this treatment method is effective in treating the primary disease while avoiding normal tissue complications. This research was introduced in the ICRP Report 89, which was published by the International Commission on Radiation Units & Measurements in 2016 to standardize the brachytherapy for cervical cancer globally, and contributed to establishment of comprehensive evaluation method in radiotherapy.

Free Research Field

放射線腫瘍学