Radiosensitive change by the Hsp90 inhibitor combination carbon ion radiotherapy.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861072
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: MUSHA ATSUSHI 群馬大学, 重粒子線医学推進機構, 助教 (60637122)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: Hsp90阻害剤 / 炭素線治療

Outline of Final Research Achievements

Carbon ion radiotherapy (C-ion RT) is a potential therapy for radio-resistant malignant tumors. However, in cases of progressive malignant tumors, achieving a complete response is difficult. Therefore, chemotherapy (with an Hsp90 inhibitor, 17-AAG) in combination with C-ion RT was employed. This study was designed to clarify the cell killing effect of 17-AAG, in combination with X-rays or carbon-ion beams in oral squamous cell carcinoma cells. 17-AAG and X-rays in combination showed enhanced antitumor effect compared to C-ion RT, which had an adequate antitumor effect even when used alone. The difference in the effectiveness of the two combination therapies was attributable to the difference in their therapeutic mechanisms. At high doses, the difference between the invasive effect of the combination treatments and that of the individual treatments decreased. However, since 17-AAG shows sufficient combined effects even at low doses, we investigated the invasive effects at low doses.

Free Research Field

放射線治療