Clinical application of fMRI for non-invasive evaluation of the cerebrovascular dynamics

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861074
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: The University of Tokyo
• Principal Investigator: Amemiya Shiori 東京大学, 医学部附属病院, 助教 (90631135)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: fMRI / 脳機能画像 / neuroimaging / perfusion

Outline of Final Research Achievements

We demonstrated that the temporal shift of resting-state functional MRI (rs-fMRI) signal is significantly correlated with that of cerebral perfusion in patients suffering from hypoperfusion. The rs-fMRI signal delay was also demonstrated in acute stroke core, which implies that the source of signal delay is vascular rather than neural, and, hence, is applicable to the assessment of hemodynamic impairment in patients with hypoperfusion both with and without neurologic deficit.
We also longitudinally evaluated alternation of the cognitive function and spontaneous neuronal activity using resting-state fMRI in patients suffering from spontaneous intracranial hypotension, and identified the areas showing changes in neural activity along with the improvement of cognitive function after surgical repair of cerebrospinal fluid leakage.

Free Research Field

放射線医学