Kinetic analysis of Estrogen receptpr PET imaging in gynecological tumors

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861079
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: TSUJIKAWA Tetsuya 福井大学, 高エネルギー医学研究センター, 准教授 (30380033)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: エストロゲン受容体PET / 動態解析 / 婦人科腫瘍

Outline of Final Research Achievements

Dynamic PET scan with 16α-[18F]fluoro-17β-estradiol (FES) was performed in patients with huge uterine leiomyoma. Rate constants (K1, k2, k3, k4), volume of distribution (VT) and k3/k4 (Binding potential) were obtained by 2-tissue compartmental modeling. They were compared with standardized uptake values at the time of 60 min after tracer injection. Binding potential and VT showed significantly positive correlations with SUV. This result indicates that FES PET kinetic analysis is feasible in gynecological tumors and that SUV is properly-validated.

Free Research Field

PET分子イメージング